New daily persistent headache (NDPH) is an unhelpful myth

December 26, 2020

Researchers in Cincinnati, OH led by Dr. Andrew Hershey reviewed information about the diagnosis, headache features, medication overuse, functional disability in a group of 1,170 children and adolescents with continuous headaches. They compared patients given the diagnosis of chronic migraine with those who were diagnosed as having new daily persistent headache.

The mean age was 14 and 79% of the group were girls. The authors reported that “The overwhelming majority of these youth had headaches with migrainous features, regardless of their clinical diagnosis. Most youth with continuous headache experienced severe migraine-related functional disability, regardless of diagnostic subgroup.”

They concluded that “Overall, youth with continuous chronic migraine and new daily persistent headache did not have clinically meaningful differences in headache features and associated disability. Findings suggest that chronic migraine and new daily persistent headache may be variants of the same underlying disease.”

Here is my take on NDPH adapted from the soon-to-be-released book, The End of Migraine: 150 Ways to Stop Your Pain:

New daily persistent headache (NDPH) is one of the dozens of types of headaches listed in the classification of headaches. This particular listing causes more harm than good. NDPH is defined by the single fact that the headache begins on a certain day and persists without a break. The classification says that NDPH may have features suggestive of either migraine or tension-type headache.

There are no parallels to NDPH in medicine. There is no new daily persistent asthma, or new daily persistent colitis, or any other “new daily” disease.

There does not appear to be any justification for having NDPH as a distinct condition. It does not have a typical clinical presentation and it has not led to any research or treatment. When you search for this condition on the internet, you will not find any effective treatment for it. The suffering of many patients is magnified by the loss of hope, worsening depression, and flagging will to live.

Most importantly, some patients with NDPH do respond to treatment. According to anecdotal reports and in my experience, Botox injections, intravenous magnesium, preventive drugs for migraines, and other treatments can be effective.

Written by
Alexander Mauskop, MD
Continue reading
July 3, 2026
Alternative Therapies
Essential Oils Can Change Your Brain
The science of essential oils and the brain is still young, but the findings so far are more compelling than many people realize. Brain imaging studies show that common scents like rose, lavender, peppermint, and lemon produce measurable changes in brain structure, brain activity, and pain processing. These studies are small and preliminary, and essential oils are not a substitute for medical treatment. But the evidence suggests that what we smell can influence the brain in real, physical ways
Read article
June 30, 2026
Alternative Therapies
Why I Ask You to Breathe Out When I Inject Botox
Incorporating slow, prolonged exhalation into procedures such as Botox injections offers a practical, evidence‑informed way to reduce discomfort and anxiety. By aligning the injection with the out‑breath, we engage parasympathetic and attentional mechanisms that help the brain process pain signals less intensely. This simple breathing cue does not replace careful technique or other comfort measures, but it complements them and gives patients an active role in their own pain control. As research on breathing and pain continues to grow, integrating this kind of mind–body strategy into migraine care becomes an increasingly important part of modern neurology.
Read article
June 29, 2026
Migraine status
Intravenous treatment for severe migraine
When you need intravenous drugs, in an ER or our office
Read article
Insights from Dr. Alexander Mauskop on headaches and migraines
Subscribe to the Blog.
Subscribe
Subscribe