Functional brain networks in migraine and meditation

April 9, 2023

I’ve previously written about the benefits of meditation and how it has helped alleviate my migraines. I recommend it to all of my patients.

A recent study published in the Journal of Headache and Pain by Chinese researchers examined changes in resting-state functional networks in the brain and their correlation with clinical traits in migraine patients.

The study used EEG and fMRI to compare 24 migraine patients with 26 healthy controls. The subjects were evaluated for migraine-related disability using the MIDAS score, cognitive functioning, anxiety, and depression.

The researchers found that the decrease of functional connectivity within the default mode network (DMN) and between DMN and executive control network (ECN) in migraine patients was negatively correlated with MIDAS score.

They also found differences in various other functional networks, but the difference in DMN connectivity caught my attention because of its association with meditation. Studies using fMRI have shown that engaging in meditation leads to a decrease in DMN activity and an increase in the activation of brain regions responsible for cognitive and emotional regulation.

Altered connectivity in the DMN has been associated with a range of neuropsychiatric conditions such as depression, anxiety, post-traumatic stress disorder, attention deficit hyperactive disorder, and obsessive-compulsive disorder. Psychedelics are also thought to produce their effect, at least in part, by acting on the DMN.

Written by
Alexander Mauskop, MD
Continue reading
August 8, 2026
Sugar is bad for your brain, even before you are born.
Sugar consumed in the first two years of life increases the risk of dementia.
Read article
August 6, 2026
Research
An Old Medicine that Could Make Brain Stimulation Work Better for Depression and Other Neurological Conditions
A 2022 clinical trial from the University of Calgary found that adding low‑dose D‑cycloserine (DCS), a partial NMDA‑receptor agonist, to intermittent theta‑burst stimulation (iTBS) significantly increased response and remission rates in depression without serious side effects. Early follow‑up data suggest that timing, dose, and drug levels matter, and raise the possibility that this DCS‑TMS approach could eventually be applied to other neurological conditions—such as migraine, postconcussion syndrome, brain fog, and long COVID
Read article
Insights from Dr. Alexander Mauskop on headaches and migraines
Subscribe to the Blog.
Subscribe
Subscribe