Yet another side effect of Topamax

April 20, 2015

Topiramate (Topamax) is a drug used for the prevention of migraine headaches (and epilepsy) in adults and last year it was also approved for adolescent migraine sufferers. This drug is notorious for causing cognitive side effects, kidney stones,osteoporosis, overheating, and many other side effects. It is contraindicated (just like another migraine drug, Depakote) in pregnancy because of the risk of birth defects.

A new report published in the journal Pediatrics documents an increased risk of eating disorders in adolescents who take Topamax. This report describes 7 female teenagers who developed an eating disorder or whose eating disorder got worse on topiramate.

Considering that we have many other effective preventive drugs for migraine headaches, topiramate should be used only when several other treatments fail.

Written by
Alexander Mauskop, MD
Continue reading
December 15, 2025
Alternative Therapies
Could drugs like Ozempic, Saxenda, and Zepbound help migraines?
Could drugs like Ozempic, Saxenda, and Zepbound help migraines? Extra weight often increases migraine headache frequency and makes standard treatments less effective. But a study just published in the journal Headache shows that a medication commonly used for weight loss and diabetes, liraglutide (Saxenda), might offer relief for tough-to-treat migraines in people with obesity.
Read article
November 15, 2025
Cluster headaches
Cluster headaches and solar activity
It was an unusual week at the New York Headache Center. After months of relative calm, my schedule suddenly filled with cluster headache patients—one even consulting me virtually from Saudi Arabia. The influx came right after a G5-level geomagnetic storm, one of the strongest solar events in recent memory.
Read article
November 10, 2025
Alternative Therapies
A Week of Meditation Changes Brains and Bodies
A week-long meditation retreat produces dramatic changes in brain and metabolic functions
Read article