Meditation is more effective than placebo

December 19, 2015

Meditation is growing in popularity and deservedly so. Several of my previous posts mentioned the benefit of meditation in migraine headaches. Scientists are conducting rigorous studies that repeatedly show the profound effect meditation has on the brain. The most recent study was done at the Wake Forest Baptist Medical Center and it compared the effect of meditation and placebo on pain.

The study was published in the recent issue of the Journal of Neuroscience. It showed that mindfulness meditation not only provided greater pain relief than placebo, but the brain scans could differentiate patterns of brain activity during meditation from that induced by placebo.

The study involved seventy five healthy, pain-free volunteers who were randomly assigned to one of four groups: mindfulness meditation, placebo meditation (“sham” meditation), placebo analgesic cream or control.

Pain was induced by heat applied to the skin. The mindfulness meditation group reported that pain intensity was reduced by 27 percent and the emotional aspect of pain (how unpleasant it was) by 44 percent. In contrast, the placebo cream reduced the sensation of pain by 11 percent and emotional aspect of pain by 13 percent.

Mindfulness meditation reduced pain by activating brain regions associated with the self-control of pain while the placebo cream lowered pain by reducing brain activity in pain-processing areas.

Another brain region, the thalamus, was deactivated during mindfulness meditation, but was activated during all other conditions. This brain region serves as a gateway that determines if sensory information is allowed to reach higher brain centers. By deactivating this area, mindfulness meditation may have caused signals about pain to simply fade away, said Dr. Zeidan, one of the researchers.

Mindfulness meditation also was significantly better at reducing pain intensity and pain unpleasantness than the placebo meditation. The placebo-meditation group had relatively small decreases in pain intensity (9 percent) and pain unpleasantness (24 percent). The study findings suggest that placebo meditation may have reduced pain through a relaxation effect that was associated with slower breathing.

This study is the first to show that mindfulness meditation does not relieve pain the way placebo does. This study confirms previous observations that as little as four 20-minute daily sessions of mindfulness meditation could enhance pain treatment. Another study has shown that an 8-week course of mindfulness meditation not only relieved pain but also made certain parts of the brain cortex measurably thicker.

Written by
Alexander Mauskop, MD
Continue reading
July 3, 2026
Alternative Therapies
Essential Oils Can Change Your Brain
The science of essential oils and the brain is still young, but the findings so far are more compelling than many people realize. Brain imaging studies show that common scents like rose, lavender, peppermint, and lemon produce measurable changes in brain structure, brain activity, and pain processing. These studies are small and preliminary, and essential oils are not a substitute for medical treatment. But the evidence suggests that what we smell can influence the brain in real, physical ways
Read article
June 30, 2026
Alternative Therapies
Why I Ask You to Breathe Out When I Inject Botox
Incorporating slow, prolonged exhalation into procedures such as Botox injections offers a practical, evidence‑informed way to reduce discomfort and anxiety. By aligning the injection with the out‑breath, we engage parasympathetic and attentional mechanisms that help the brain process pain signals less intensely. This simple breathing cue does not replace careful technique or other comfort measures, but it complements them and gives patients an active role in their own pain control. As research on breathing and pain continues to grow, integrating this kind of mind–body strategy into migraine care becomes an increasingly important part of modern neurology.
Read article
June 29, 2026
Migraine status
Intravenous treatment for severe migraine
When you need intravenous drugs, in an ER or our office
Read article
Insights from Dr. Alexander Mauskop on headaches and migraines
Subscribe to the Blog.
Subscribe
Subscribe