Stabbing headaches as a sign of MS

September 22, 2014

Stabbing headaches can be a sign of acute multiple sclerosis, according to a report by German doctors in the journal Headache. Stabbing headache is a rare type of headache, although patients with migraines often report having occasional “ice pick” headaches. Some call these headaches “jabs and jolts”. In some people, stabbing headaches can be quite disabling. The pain lasts only a couple of seconds but can occur up to 100 times a day. Treatment usually involves indomethacin or another non-steroidal anti-inflammatory medication in the aspirin family (including our own Migralex). However, in this case where stabbing headaches were associated with MS, treating MS relieved headaches as well.

In a prior report in Clinical Neurology and Neurosurgery Italian physicians also found that of 26 patients with stabbing headaches they had seen over 10 years, more than half had autoimmune disorders, including multiple sclerosis, Sjögren’s disease, lupus, Behçet’s disease, autoimmune vasculitis, and antiphospholipid antibody syndrome. The authors speculated that stabbing headache may develop as a result of inflammation in the brain with loss of myelin around the nerve fibers, which is seen with MS and other auto-immune disorders.

Written by
Alexander Mauskop, MD
Continue reading
April 20, 2026
Can the Air You Breathe and the Weather Outside Trigger Your Migraines?
A major new study of over 7,000 migraine patients tracked two decades of air pollution, temperature, and humidity data, and found that the environment isn't just a background player. It's an active trigger.
Read article
April 17, 2026
Research
Not All Young Children Just “Bounce Back” from Concussion
A new study challenges the belief that young children quickly recover from concussions, showing that symptoms can persist for months and highlighting the importance of early evaluation and care.
Read article
April 10, 2026
Research
Migraines often strike on one side. Scientists say that matters more than we think
Migraines often strike on one side. Scientists say that matters more than we think New data may improve outcomes when we use TMS to treat migraines
Read article
Insights from Dr. Alexander Mauskop on headaches and migraines
Subscribe to the Blog.
Subscribe
Subscribe