Antibiotic for daily headache?
Doxycycline has been reported to relieve treatment-resistant new daily persistent headache in four patients. The dose was 100 mg twice a day and was given for 3 months. One of the patients responded after two weeks, but the average response time was 2 months. The lead author of the study, Dr. Todd Rozen speculated that the reason for improvement is the fact that doxycycline is not only an antimicrobial drug, but also acts as an anti-inflammatory agent.
I submit that an undetected bacteria possibly a spirochete is in the meninges and CSF. Penicillin and Probenecid treatment and thorough testing of the CSF may tell us more. Doxycycline treatment with 400 mg daily for 28 day also works but not in all patients.
Unfortunately, there have been no additional studies.
Can you tell me more about New Daily Persistent Headaches? Has there been more evidence that Doxycycline works? Thank you.